Creative Biolabs

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1. Sep 06, 2023
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   By Creative Biolabs

   Ad fiber knob CD40 scFv Fc scFv: Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-Ad fiber knob scFv is fused to the N-terminus of Fc via a hinge region while another anti-CD40 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: https://www.creative-biolabs.com/bsab/bispecific-ad-fiber-knob-cd40-scfv-fc-6980.htm