Exosomes serve a crucial part in cell-to-cell communication by carrying different kinds of proteins, lipids, and nucleic acids (mRNA and non-coding RNA). Exosomes also have favorable characteristics that make them a good choice for drug delivery, including high delivery effectiveness, a long half-life in circulation, the innate capacity to target tissues, biocompatibility, and little to no inherent toxicity problems. The ability of exosomes to direct therapeutic cargo through natural membrane barriers, such as the blood-brain barrier (BBB), is crucial for improving the therapeutic effectiveness of brain illnesses. So, it makes sense to use exosomes as delivery systems for treatments to reach their target cells. Exosomes should be loaded with various therapeutic payloads, such as tiny chemicals, proteins, and nucleic acids, before they are delivered.